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- The series takes viewers to the epicenter of America's struggle with opioid addiction, from the boardrooms of Purdue Pharma, to a distressed Virginia mining community, to the hallways of the DEA.
- Two young women struggling to understand their swelling passions discover an unlikely ally in the form of an Iraq war veteran.
- Rick and Randy's criminal investigation now threatens Richard Sackler's empire, activists take action against Purdue, and Finnix tries to heal his beloved community that's been ravaged by addiction.