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- Using a crack team of doctors and his wits, an antisocial maverick doctor specializing in diagnostic medicine does whatever it takes to solve puzzling cases that come his way.
- When a novice sleuth convinces the police he has psychic powers, he and his reluctant best friend are hired on as consultants to help solve complicated cases.
- Three different, but related, families face trials and tribulations in their own uniquely comedic ways.
- The series follows Adrian Monk, a brilliant former San Francisco detective, who now consults the police as a private consultant whilst battling with an obsessive-compulsive disorder.
- F.B.I. Special Agent Seeley Booth teams up with the Jeffersonian's top anthropologist, Dr. Temperance Brennan, to investigate cases where all that's left of the victims are their bones.
- Follows the misadventures of four irreverent grade-schoolers in the quiet, dysfunctional town of South Park, Colorado.
- A new FBI profiler, Elizabeth Keen, has her entire life uprooted when a mysterious criminal, Raymond Reddington, who has eluded capture for decades, turns himself in and insists on speaking only to her.
- A structural engineer installs himself in a prison he helped design, in order to save his falsely accused brother from a death sentence by breaking themselves out from the inside.
- A young Clark Kent struggles to find his place in the world as he learns to harness his alien powers for good and deals with the typical troubles of teenage life in Smallville, Kansas.
- A young woman with a troubled past is drawn to a small town in Maine where fairy tales are to be believed.
- When a beautiful stranger leads computer hacker Neo to a forbidding underworld, he discovers the shocking truth--the life he knows is the elaborate deception of an evil cyber-intelligence.
- In Las Vegas, a squad of forensic investigators are trained to solve crimes by meticulously examining the evidence. They employ advanced technology and their rationality to detect the perpetrators.
- Professional writer and amateur sleuth Jessica Fletcher uses her intellect, charm, and persistence to get to the bottom of every crime she encounters.
- Marty McFly, a 17-year-old high school student, is accidentally sent 30 years into the past in a time-traveling DeLorean invented by his close friend, the maverick scientist Doc Brown.
- Los Angeles homicide detective Lieutenant Columbo uses his humble ways and ingenuous demeanor to winkle out even the most well-concealed of crimes.
- In Nazi-occupied France during World War II, a plan to assassinate Nazi leaders by a group of Jewish U.S. soldiers coincides with a theatre owner's vengeful plans for the same.
- A city doctor is forced to work in the remote Alaskan town of Cicely, where he encounters peculiar locals, including a former astronaut, as he adjusts to small-town life.
- Three parapsychologists forced out of their university funding set up shop as a unique ghost removal service in New York City, attracting frightened yet skeptical customers.
- An adolescent with two siblings tests his various theories about life as he endures the trials of growing up alongside a good friend.
- The regulars of the Boston bar "Cheers" share their experiences and lives with each other while drinking or working at the bar where everybody knows your name.
- Genetic engineers Clive Nicoli and Elsa Kast hope to achieve fame by successfully splicing together the DNA of different animals to create new hybrid animals for medical use.
- An unfairly discredited but brilliant ER doctor winds up working with his younger brother in the Hamptons as a concierge doctor to the uber-rich and ultra-elite.
- The misadventures of a talking sea sponge who works at a fast food restaurant, attends a boating school, and lives in an underwater pineapple.
- The sole survivor of a pier shoot-out tells the story of how a notorious criminal influenced the events that began with five criminals meeting in a seemingly random police lineup.
- A linguist works with the military to communicate with alien lifeforms after twelve mysterious spacecraft appear around the world.