Billy Gardell and Reno Wilson are good friends in real life. They had been looking for a project they could do together when Gardell was approached about this show. They agreed it was an ideal situation, and Gardell asked for Wilson to be brought in.
Billy Gardell and Reno Wilson had previously been police partners in Heist (2006). Billy Gardell also played Officer Hoyn on My Name Is Earl (2005).
The show got its name from "Mike & Molly's," a bar in Champaign, Illinois.