While apparently set in Seattle, filming is mostly done in Los Angeles. The fire-station's exterior establishing shots are from the Seattle Fire Department's actual Station 20 (there is no real-world 'Station 19'), located on 15th Avenue West on Queen Anne's west side.
This is the second Grey's Anatomy (2005)'s spin-off series. Likewise set in Seattle, the fictional 'Station 19' is located just three blocks from the fictional 'Grey Sloan Memorial Hospital'. The first spin-off, Private Practice (2007), is set in Southern California.
Before starring in Station 19 and its parent show Grey's Anatomy in 2018 as Pruitt Herrera, Miguel Sandoval appeared in a 2012 episode of Grey's Anatomy as Hank, the partner of a patient undergoing a liver transplant.
Maya Bishop has a gold medal from the women's 10,000 meters at the 2012 Olympics in London. In real life, that medal was won by Tirunesh Dibaba of Ethiopia.